【摘 要】
：
Objective: To study the effect of Buyang Huanwu Decoction (补阳还五汤BYHWD) on spinal ischemia-reperfusion injury and explore the possible mechanism involved. M
【机 构】
：
Department of Orthopedics, Second AffiliatedHospital of Xi’an Jiaotong University, Xi’an 710004, Chi
论文部分内容阅读
Objective: To study the effect of Buyang Huanwu Decoction (补阳还五汤BYHWD) on spinal ischemia-reperfusion injury and explore the possible mechanism involved. Method: 27 model rabbits with ischemia-reperfusion injury were randomly divided into a sham operation group, a model group and a BYHWD-pre-treated group. 24 and 48 hours after the ischemia-reperfusion injury, the motor functions of hind limbs were observed, the expressions of apoptosis-related proteins bcl-2 and Bax in the spinal tissue were investigated with the immunohistochemical methods and apoptosis of nervous cells with TUNEL straining; and the malondialdehyde (MDA) level and superoxide dismutase (SOD)activity in the spinal cord were then determined. Results: BYHWD can improve significantly the motor function of hind limbs, increase SOD activity and decrease the level of MDA, up-regulate expression of Bcl-2 and down-regulated expression of Bax, and depress apoptosis of nervous cells in the spinal cord caused by the ischemia reperfusion in the rabbits. Conclusion: BYHWD has a protective action on the spinal ischemia-reperfusion injury, and the mechanisms may be related to the decrease of lipid peroxidation and inhibition of apoptosis of nervous cells.
其他文献
Tension headache is a most common type of headache, which falls into the category of Toutong (头痛 headache), or Toufeng (头风 head-wind) in TCM. It is charact
Objective: To observe the curative effect of the method of replenishing qi, promoting blood circulation and resolving phlegm on senile hyperlipemia and its effe
Objective: To evaluate the effect of modified Banxia Xiexin Tang (半夏泻心汤 Pinellia Decoction for Draining the Heart) in treatment of laryngopharyngitis cause
目的 探讨ABCD3-I评分法结合纤维蛋水平白原检测对短暂性脑缺血发作(TIA,Transient ischemic attack)短期发生脑梗死的风险进行评估.方法 用ABCD3-I评分法和ABCD3-I评分法+纤
Dr. Gao Huiyuan (1922- 2002) was b in a family of doctors of TCM who have practiced for generations, and was later a student of the well-known TCM expert Pu Fu
目的比较手针与电针对于缺血性脑卒中偏瘫患者的治疗效果。方法选取本院针灸科收治的200例缺血性脑卒中偏瘫患者作为研究对象,按照治疗方法分为手针组与电针组,各100例;在药
小儿高热惊厥,它是儿科常见急症之一,发生率高,约为成人的10-15倍,多见于6个月-3岁的小儿.因为这个阶段的小儿大脑发育不够完善,抑制能力差,以致弱的刺激也能在大脑引起强烈
The effects of acupuncture on bone biomechanical properties and histomorphometry in ovariectomized (OVX) rats were studied. Twenty-four 8-week-old female Spragu
Systemic scleroderma (SSc) is a progressive dermatosis with symmetric skin sclerosis and ischemia of the fingers or toes, accompanied with lesions of the joint
This study is to investigate the effects of electroacupuncture at acupoints of the Govor Vessel(GV) on aquaporin-4 (AQP-4) expression and on functions of the hi