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测定了164名(20～89岁)原发性高血压病患者和40名不同年龄健康人的血浆肾素活性和醛固酮浓度。结果表明,年轻组和老年组高血压病患者血浆肾素活性和醛固酮浓度均有显著变化,其程度与疾病的轻重有关。第一型老年高血压患者血浆肾素活性升高或正常,而第二型老年高血压病患者血浆肾素活性呈低值,但醛固酮浓度显著升高。故治疗时第一型患者应给予β—肾上腺阻滞剂,而第二型患者应给予醛固酮的竞争性拮抗剂。
Plasma renin activity and aldosterone concentrations were measured in 164 patients (20-89 years old) with essential hypertension and 40 healthy people of different ages. The results showed that the plasma renin activity and aldosterone concentrations of hypertensive patients in both young and old groups both had significant changes, which were related to the severity of the disease. Plasma renin activity is elevated or normal in type 1 elderly hypertensive patients, whereas plasma renin activity is low in type 2 elderly hypertensive patients, but aldosterone concentrations are significantly elevated. Therefore, the first type of treatment should be given β-adrenergic blockers, while the second type of patients should be given aldosterone competitive antagonist.