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实验性肾细胞瘤根据其染色的不同,一般可分为嗜硷细胞瘤、大嗜酸粒细胞瘤和明细胞瘤。最近,通过对比这些肿瘤的早期病变与正常肾小营的相似性,以及变异酶的表现特征与肿瘤的连续性,发现通过一个变异的肾小管,便可明确识别各型肿瘤的早期病变。嗜硷性变异肾小管上皮,其6-磷酸葡萄糖脱氢酶(G-6-PDH)的活性很高;局部的解毒酶A型谷胱甘肽-S-转移酶(GST2-2)、细胞色素-P-450PB3a和环氧化合物水解酶等免疫组织化学物增加;线粒体中的琥珀酸盐氢化酶(SDH)的活性消失。而且在
Experimental renal cell tumor according to their different staining can be divided into general oncocytoma, eosinophoblastoma and oncocytoma. Recently, comparing the early lesions of these tumors with those of normal renal tubules, and the characterization of the mutant enzymes and the continuity of the tumors, we found that the early lesions of various types of tumors can be clearly identified through a variant tubule. Alkalophilic variant renal tubular epithelial cells are highly activated by 6-phosphoglucose dehydrogenase (G-6-PDH); local detoxifying enzyme type A glutathione-S-transferase (GST2-2) Pigment-P-450PB3a and epoxide hydrolase and other immunohistochemicals increased; mitochondrial succinate hydrogenase (SDH) activity disappeared. And at