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目的探讨hMSH2和FHIT基因在宫颈癌发生、发展过程中的作用及其相互关系。方法应用免疫组织化学SP法对35例宫颈癌、10例宫颈上皮内瘤变(CIN)和30例正常宫颈组织中FHIT、hMSH2的表达进行检测。结果浸润性宫颈癌、CIN、正常宫颈组织标本中hMSH2蛋白表达的阳性率分别为60.0%、70.0%和30.0%,差异有统计学意义(P<0.05);FHIT蛋白在浸润性宫颈癌、CIN和正常宫颈组织中异常表达率分别为62.9%、40%和0%,三者间差异有统计学意义(P<0.05);在35例浸润性宫颈癌病例中,hMSH2与FHIT无明显相关性(rs=-0.097,P>0.05)。结论 hMSH2在宫颈癌变过程中可能起一定作用。FHIT在宫颈癌的发生发展中起着重要作用;两者在宫颈癌中表达改变不相关。
Objective To investigate the roles and relationships of hMSH2 and FHIT genes in the development and progression of cervical cancer. Methods The expressions of FHIT and hMSH2 in 35 cases of cervical cancer, 10 cases of cervical intraepithelial neoplasia (CIN) and 30 cases of normal cervical tissue were detected by immunohistochemical SP method. Results The positive rates of hMSH2 protein expression in invasive cervical cancer, CIN and normal cervical tissues were 60.0%, 70.0% and 30.0%, respectively (P <0.05). The positive rates of FHIT protein in invasive cervical cancer, CIN And normal cervical tissues were 62.9%, 40% and 0%, respectively, with statistical significance (P <0.05). There was no significant correlation between hMSH2 and FHIT in 35 cases of invasive cervical cancer (rs = -0.097, P> 0.05). Conclusion hMSH2 may play a role in cervical carcinogenesis. FHIT plays an important role in the occurrence and development of cervical cancer. The expression of FHIT in cervical cancer is not correlated.