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H_2受体拮抗剂临床应用以前,有关消化溃疡自然病程的大量研究提示:①消化性溃疡通常是长期的,可能是终生的疾病;②在诊断后约7～8年症状最严重且并发症多;③在同期内有15～50％的患者需手术治疗;④个体差异很大因而只有总体结果可预测。
H 2 receptor antagonist before the clinical application of the natural history of peptic ulcer a large number of studies suggest that: ① peptic ulcer is usually long-term, may be a lifetime of disease; ② about 7 to 8 years after diagnosis the most severe symptoms and complications ; ③ 15 to 50% of patients require surgical treatment during the same period; and ④ Individuals vary greatly and thus only the overall outcome is predictable.