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各型儿童癫痫(除失神发作及婴儿痉挛外)的治疗有效率还了解甚少。本文报导82例首次诊断癫痫、以往未经抗癫痫治疗的患儿始服抗痉剂后的有关情况及前瞻性研究。包括1次癫痫发作伴EEG性放电者、2次或2次以上无诱因的非发热性抽搐者(不论EEG是否异常)。发热抽搐、急性脑病、脑瘤或脑变性疾病引起的抽搐,以及严重精神发育迟滞患者予以删除。治疗前均作血和尿液检查,包括全血细胞和血小板计数、SGOT、硷性磷酸酶、胆红素等。接受丙戊酸治疗者还测定血清纤维蛋白原和淀粉酶。根据临床诊断选用抗痉剂后,在1、3、6、12月时进行体查,此后每六个月一次,同时重复上述血液检查并测抗痉剂血浓度(服氯硝安定者例外)。82例中男53例,女29例,平均年龄7.5岁,其中
Little is known about the effectiveness of treatment for all types of childhood epilepsy (except for missed seizures and infantile spasms). This article reports 82 cases of the first diagnosis of epilepsy, antiepileptic treatment in children without antiepileptic agents after the onset of the situation and prospective study. Including a seizure with EEG discharge, 2 or more non-induced non-febrile seizures (regardless of EEG is abnormal). Febrile seizures, acute encephalopathy, convulsions caused by brain tumors or degenerative diseases, and patients with severe mental retardation. Blood and urine tests were performed before treatment, including whole blood cells and platelet counts, SGOT, alkaline phosphatase, bilirubin and the like. Patients receiving valproate also measured serum fibrinogen and amylase. According to the clinical diagnosis of antispasmodic agent, at 1,3,6,12 months when the body check, then every six months, at the same time repeat the blood test and test antispasmodic blood concentration (clonazepam servants exception) . 82 cases of male 53 cases, 29 females, mean age 7.5 years, of which