Mitochondrial malfunction in vanishing white matter disease:a disease of the cytosolic translation m

• 作 者: Orna Elroy-Stein
• 机 构: Dept of Cell Research and Immunology,George S.Wise Faculty of Life Sciences,Sagol School of Neurosci
• 出 处: Neural Regeneration Research
• 发表日期: 2017年10期
• 关键词: cytosolic machinery vanishing recessive OMIM encoding prevalence mitochondrial p

Vanishing white matter(VWM)disease–a disease of the cytosolic translation machinery:VWM is a recessive genetic neurodegenerative disease caused by mutations in any of the five genes encoding the subunits of translation initiation factor 2B(e IF2B)(Leegwater et al.,2001;OMIM 306896).This cure-less disease is rare(rough estimation would be around 1:100,000),but the actual prevalence is thought

Vanishing white matter (VWM) disease-a disease of the cytosolic translation machinery: VWM is a recessive genetic neurodegenerative disease caused by mutations in any of the five genes encoding the subunits of translation initiation factor 2B (e IF2B) (Leegwater et al. 2001; OMIM 306896). This cure-less disease is rare (rough estimation would be around 1: 100,000), but the actual prevalence is thought