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目的探讨内皮素(ET)水平在慢性肾脏疾病发生、发展中所起的作用。方法采用放射免疫法对正常人和慢性肾脏疾病患者血浆、尿ET-1进行检测,同时测定其血肌酐(Scr)、尿β2-微球蛋白的值,计算肌酐清除率(Ccr)。结果各期慢性肾脏病患者血、尿ET-1、β2-MG均较正常人升高,差异有显著性意义(P<0.01)。β2-MG与Scr呈显著正相关(P<0.01),β2-MG与尿ET-1亦呈显著正相关(P<0.01)。血、尿ET-1均与Scr呈显著正相关(P<0.01),血ET-1与Ccr呈显著负相关(r=0.780,P<0.01),尿ET-1与Ccr呈显著负相关(r=0.888,P<0.01),且尿ET-1与Ccr相关性较血ET-1与Ccr相关性更强。结论尿ET-1与慢性肾脏病的发生、发展关系密切。
Objective To investigate the role of endothelin (ET) in the occurrence and development of chronic kidney disease. Methods Plasma and urinary ET-1 levels were measured by radioimmunoassay in normal subjects and patients with chronic kidney disease. Serum creatinine (Scr) and urinary β2-microglobulin were measured at the same time, and creatinine clearance (Ccr) was calculated. Results The levels of blood and urine ET-1 and β2-MG in patients with chronic kidney disease were significantly higher than those in normal controls (P <0.01). There was a significant positive correlation between β2-MG and Scr (P <0.01), β2-MG and urinary ET-1 (P <0.01). There was a significant positive correlation between plasma ET-1 and Scr (P <0.01), ET-1 and Ccr were negatively correlated (r = 0.780, P <0.01) r = 0.888, P <0.01). The correlation between urinary ET-1 and Ccr was more significant than ET-1 and Ccr. Conclusions Urinary ET-1 is closely related to the occurrence and development of chronic kidney disease.