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用醛氢叶酸（ＣＦ）与氟尿嘧啶（５ＦＵ）治疗经病理证实的晚期胃肠道癌１７例，其中胃癌８例，大肠癌９例。ＣＦ每次２００毫克，静滴２小时，５ＦＵ每次１克，于ＣＦ滴至一半时用；静滴１４小时以上，连用５天，２１天重复。结果：总有效率（ＣＲ＋ＰＲ）４７．１％。其中初治８例，有效率为６２．５％，复治９例（曾用过５ＦＵ或ＦＴ一２０７治疗），有效率３３．３％。胃癌与大肠癌有效率分别为５％和４４．４％。１７例中除１例进展外．其余１６例化疗后临床症状均有减轻或消失，生活质量提高。随访：全组中位生存期１１个月。胃癌８例，存活４～２２个月（中位生存期８个月），大肠癌９例，存活４～２１个月（中位生存期１６个月），其中５例已死亡，４例至今己分别存活１４、１６、１６、１７个月。毒性反应以静脉炎多见，占７０．６％，其他尚有消化道反应。谷丙转氨酶升高，均为Ⅰ～Ⅱ级毒性反应。晚期胃肠道癌病人体质差，本法毒性小，能耐受，疗效达４７．１％，值得进一步研究。
Five cases of advanced gastrointestinal cancer confirmed by pathology were treated with leucovorin (CF) and fluorouracil (5FU), including 8 cases of gastric cancer and 9 cases of colorectal cancer. Each time 200 mg of CF was instilled for 2 hours, 5FU of each was used for 1⁄2 of the time, CF was used at half the time; Intravenous IV was used for more than 14 hours for 5 days, and 21 days were repeated. Results: The total effective rate (CR+PR) was 47.1%. Among them, 8 cases were initially treated, the effective rate was 62.5%, 9 cases were retreated (5FU or FT-207 treatment was used), and the effective rate was 33.3%. The effective rates of gastric cancer and colorectal cancer were 5% and 44.4%, respectively. In 17 cases except 1 case progress. The clinical symptoms of the remaining 16 patients after chemotherapy all reduced or disappeared, and their quality of life improved. Follow-up: The median survival time was 11 months. 8 cases of gastric cancer, survival 4 to 22 months (median survival period of 8 months), 9 cases of colorectal cancer, survival 4 to 21 months (median survival period of 16 months), of which 5 cases have died, 4 cases so far They have survived for 14, 16, 16 and 17 months respectively. The most common toxic reaction was phlebitis, which accounted for 70.6%. Others had gastrointestinal reactions. Increased alanine aminotransferase levels were grade I-II toxicities. The patients with advanced gastrointestinal cancer have poor physique. The toxicity of this method is small, can be tolerated, and the efficacy is 47.1%. It is worth further study.