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目的 :研究胃星星秘方对实验性胃溃疡的防治作用。方法 :采用吲哚美辛 (消炎痛 )致胃溃疡、幽门结扎型胃溃疡、应激性胃溃疡、醋酸性胃溃疡等大鼠胃溃疡模型 ,观察胃星星秘方对胃溃疡防治作用的影响 ,并与胃苏颗粒、三九胃泰、法莫替丁的疗效进行比较。结果 :胃星星秘方对大鼠吲哚美辛性胃溃疡和幽门结扎型胃溃疡预防效果好 ,与盐水对照组有显著差别 (P <0 .0 1) ,效果优于或相当于对照药 ,溃疡抑制率 >6 0 % ,对大鼠醋酸性胃溃疡和应激性胃溃疡基本无效。结论 :胃星星秘方对动物实验性胃溃疡具有一定的预防作用 ,药效与胃苏颗粒、三九胃泰相当。
Objective : To study the preventive and therapeutic effects of Weixingxing Mifang on experimental gastric ulcer. METHODS: Gastric ulcers caused by indomethacin (indomethacin), pylorus-ligated gastric ulcers, stress gastric ulcers, and acetic acid-induced gastric ulcers were used to observe the effects of Weixingxing Mifang on gastric ulcer prevention and control. And compared with Wei Su granules, Sanjiuweitai, famotidine’s efficacy. RESULTS: Weixingxingmi Prescription had a good preventive effect on indomethacin-induced gastric ulcer and pylorus-ligated gastric ulcer in rats, and was significantly different from saline control group (P < 0.01). The effect was better than or equal to the control drug. The ulcer inhibition rate was more than 60%, which was basically ineffective in rats with acetic acid ulcer and stress gastric ulcer. Conclusion : Wei Xing Xing Mi Fang has a certain preventive effect on experimental gastric ulcers in animals, and its efficacy is comparable to Wei Su Granules and Sanjiu Weitai.