论文部分内容阅读
目的报道1例起源于阴道的骨骼外尤文肉瘤/原始神经外胚层瘤(ES/PNET),结合文献资料,复习其临床、病理、超微结构、免疫表型、细胞基因、鉴别诊断、治疗及预后等。方法该病例选自天津市病理会诊中心2001-06—2005-06间的1998例疑难病理标本,经常规制片,HE染色,又辅以免疫组化染色。结果阴道肿物呈带蒂息肉,由幼稚核深染小圆细胞组成,免疫组化呈神经及肌源性双向免疫表型,病理诊断阴道原发性ES/PNET。结论ES/PNET诊断标准除原始小细胞外常向神经分化,必须具备免疫组化CD99及神经内分泌标记2项以上阳性,细胞遗传学分析有染色体易位t(11;22)(q24;q12)。
OBJECTIVE: To report one case of extraosseous eosinosarcoma / primitive neuroectodermal tumor (ES / PNET) originated from the vagina and to review its clinical, pathological, ultrastructural, immunophenotypic, cellular gene, differential diagnosis, Prognosis and so on. Methods The cases were selected from 1998 pathological specimens from 1998 to 2005 in Tianjin Pathological Consultation Center. The routine specimens were stained with HE and supplemented with immunohistochemistry. Results The vaginal mass was pedunculated polyps, which consisted of immature nuclear stained small round cells. Immunohistochemistry showed the bilateral immunophenotypes of neurons and myogenic origin. The pathological diagnosis of primary vaginal ES / PNET was made. Conclusion ES / PNET diagnostic criteria, in addition to primitive small extracellular extracellular differentiation must have immunohistochemical CD99 and neuroendocrine markers more than 2 positive, cytogenetic analysis of chromosomal translocation t (11; 22) (q24; q12) .