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在1978年7月至1988年4月间Bowman Gray医学院对71 563例妇女进行了母血清甲胎蛋白(MSAFP)普查。其中1 843例(2.5%)MSAFP升高,等于或大于中值的2.5倍,并提供超声评价和可能的羊膜腔穿刺术。共727例妇女(1%)为测定羊水AFP进行了羊膜腔穿刺术。在727例因MSAFP升高行羊膜腔穿刺术的妇女中检出7例染色体异常,发生率达1/104。在羊水AFP结果正常的妇女中染色体异常发生率为1/109。与正常羊水AFP有关的6例染色体异常病例包括3例三倍体、2例47,XXX和1例46,XX,1q~-。另外,1例13三体与羊水AFP升高有
Between July 1978 and April 1988, Bowman Gray School of Medicine conducted a screening survey of 71 563 women with serum alpha-fetoprotein (MSAFP). Of these, 8443 (2.5%) MSAFP were elevated at 2.5 times or greater than the median and provided sonographic evaluation and possible amniocentesis. A total of 727 women (1%) underwent amniocentesis for the determination of amniotic fluid AFP. Seven cases of chromosomal abnormalities were found in 727 women with elevated amniocentesis by MSAFP, with a rate of 1 in 104. The incidence of chromosomal abnormalities in women with normal AFP in amniotic fluid was 1/109. Six cases of chromosomal abnormalities associated with normal amniotic fluid AFP included three cases of triploidy, two cases of 47, XXX and one case of 46, XX, 1q ~ -. In addition, a case of trisomy 13 and amniotic fluid AFP increased