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目的:探讨冠心病患者氧化型低密度脂蛋白(ox-LDL)的变化,评估ox-LDL水平检测的临床意义。方法:采用ELISA法测定139例冠心病患者〔急性冠状动脉综合征(ACS)103例,非ACS组86例〕和210例健康对照组人群血浆ox-LDL水平;根据冠状动脉造影结果将冠心病组分为多支病变组、双支病变组和单支病变组进行比较分析。结果:ACS组患者和非ACS组患者ox-LDL水平均显著高于健康对照组[ACS组为(185.44±70.11)mg.L-1,非ACS组(139.51±58.790)mg.L-1,对照组为(80.47±25.96)mg.L-1,P均<0.001];且ACS组患者ox-LDL水平显著高于非ACS组(P<0.001)。冠状动脉多支、双支、单支病变组ox-LDL水平分别为(180.34±76.92),(149.18.15±64.80),(137.74±58.09)mg.L-1,多支高于单支(P<0.01)。多因素分析显示冠状动脉病变程度仅与ox-LDL相关(R2=0.046,β=0.208,P=0.000)。结论:冠心病患者ox-LDL水平升高与病变程度相关,急性冠脉综合征患者变化尤为明显。
Objective: To investigate the changes of oxidized low density lipoprotein (ox-LDL) in patients with coronary heart disease and to evaluate the clinical significance of ox-LDL level. Methods: The levels of plasma ox-LDL in 139 patients with coronary heart disease (103 with acute coronary syndrome (ACS), 86 with non-ACS) and 210 healthy controls were measured by ELISA. Coronary artery disease The components were multi-vessel lesion group, double-vessel lesion group and single vessel lesion group for comparative analysis. Results: The levels of ox-LDL in ACS group and non-ACS group were significantly higher than those in healthy control group (185.44 ± 70.11 mg.L-1 in ACS group, 139.51 ± 58.790 mg.L-1 in ACS group, (80.47 ± 25.96) mg.L-1 in the control group, P <0.001, respectively). The level of ox-LDL in ACS group was significantly higher than that in non-ACS group (P <0.001). The levels of ox-LDL in multi-branch, double-branch and single-vessel coronary arteries were (180.34 ± 76.92), (149.18.15 ± 64.80) and (137.74 ± 58.09) mg.L- P <0.01). Multivariate analysis showed that the degree of coronary artery disease was only associated with ox-LDL (R2 = 0.046, β = 0.208, P = 0.000). Conclusion: The elevated level of ox-LDL in patients with coronary heart disease is related to the severity of the disease, especially in patients with acute coronary syndrome.