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目的探讨颈动脉支架置入术对无症状性颈动脉高度狭窄患者认知功能的影响。方法以本院2012年2月~2014年2月治疗的96例行颈动脉支架置入术的无症状性颈动脉高度狭窄患者为研究组,以同期90例行常规内科治疗的无症状性颈动脉高度狭窄患者为对照组,分别在治疗前3 d和治疗后3个月采用连线测验(TMTa、TMTb)、简易智能量表(MMSE)、阿尔茨海默病评估量表认知部分(ADAS-Cog)评估患者的认知功能。结果研究组患者治疗前3 d颈动脉狭窄为(79.51±6.02)%,治疗后3个月残余狭窄为(13.52±6.01)%,治疗后3个月狭窄程度较治疗前3 d有明显改善(P<0.05);治疗后研究组狭窄程度显著低于对照组(P<0.05)。与治疗前3 d相比,研究组治疗后3个月患者的MMSE评分明显增加(P<0.05),TMTa、TMTb和ADAS-Cog评分均明显降低(P<0.05);治疗3个月研究组各指标均显著优于对照组(P<0.05)。结论颈动脉高度狭窄可能造成患者认知功能损伤,即使是无症状的此类患者,行颈动脉支架置入术对患者的认知功能也具有一定的改善作用,并且可降低颈动脉狭窄程度。
Objective To investigate the effect of carotid artery stenting on cognitive function in patients with asymptomatic carotid artery stenosis. Methods A total of 96 patients with asymptomatic carotid stenosis undergoing carotid stenting in our hospital from February 2012 to February 2014 were enrolled in this study. Totally 90 asymptomatic patients with conventional medical treatment Arteriosclerosis patients were divided into control group (control group, TMTa, TMTb, MMSE, Alzheimer’s disease cognitive scale ADAS-Cog) to assess the patient’s cognitive function. Results The carotid artery stenosis was (79.51 ± 6.02)% three days before treatment in the study group, and the residual stenosis was (13.52 ± 6.01)% at 3 months after treatment. The stenosis was significantly improved at 3 months after treatment P <0.05). After treatment, the degree of stenosis in the study group was significantly lower than that in the control group (P <0.05). Compared with the 3 days before treatment, the MMSE scores of the study group increased significantly (P <0.05), TMTa, TMTb and ADAS-Cog scores decreased significantly (P <0.05) Each index was significantly better than the control group (P <0.05). Conclusion Carotid artery stenosis may cause cognitive impairment in patients. Even in asymptomatic patients, carotid artery stenting can improve the cognitive function of patients and reduce the degree of carotid artery stenosis.