茶碱沙丁胺醇缓释片对变应性哮喘作用的研究

• 作 者: 曹颖林 王玉坤 徐成 曹悦 唐星 何仲贵
• 机 构: 沈阳药科大学药学系生理学教研室,沈阳药科大学药学系药剂学教研室
• 出 处: 沈阳药科大学学报
• 发表日期: 1998年03期
• 关键词: 变应性哮喘 丁胺 过敏性哮喘 引喘潜伏期 卵蛋白 离体气管 哮喘豚鼠 致敏 支气管平滑肌 平滑肌收缩

茶碱和沙丁胺醇伍用对卵蛋白致敏豚鼠离体气管平滑肌、肺条在抗原攻击时引起的收缩反应，均有明显抑制作用．ＩＣ５０分别为９２～２３０μｇｍＬ－１和５９～２２９μｇ·ｍＬ１．茶碱／沙丁胺醇３种剂量（１２０ｍｇ／０１６ｍｇ·ｋｇ－１，２４０ｍｇ／０３２ｍｇ·ｋｇ－１，４８０ｍｇ／０６４ｍｇ·ｋｇ－１）灌胃给药明显延长过敏性哮喘豚鼠引喘潜伏期及减少致敏麻醉豚鼠的肺溢流量增加．

Theophylline and salbutamol were significantly inhibited by ovalbumin-induced contractile responses in guinea pig isolated tracheal smooth muscle and lung strips during antigen challenge. IC50 were 9  2 ~ 23  0μg mL-1 and 5  9 ~ 22  9μg · mL  1. Theophylline / albuterol 3 doses (120mg / 016mg · kg-1, 240mg / 032mg · kg-1, 480mg / 064mg · kg-1) Induction of asthmatic guinea pigs with asthma latency and reduction of sensitized anesthetized guinea pigs increased lung overflow.