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目的:对9名晚期肝脏癌肿病人施行了共14次联合血液灌流的大剂量动脉化疗。材料和方法:给药途径:4例透视下介入肝动脉置管、1例直接手术肝动脉置管,4例肝动脉置管外接皮下药物泵。药物及剂量:丝裂霉素(10～30mg,平均21.07)、顺铂(80～180mg,平均142.86)及5-氟脲嘧啶。透析情况:时间为240分钟,流量为200ml/分钟。6例病人治疗1次,2例治疗2次,1例治疗4次。每2次治疗间隙,时间为28～56天。结果:全部病人均耐受了治疗。没有发现严重的并发症。现存活4人,死亡者平均存活时间为8月。1例完全缓解(11%),2例部分缓解(22%),5例稳定(56%),1例进展(11%)。结论:大剂量动脉化疗联合血液透析可以作为晚期癌症病人的一种有效的姑息治疗方法。
OBJECTIVE: To perform a total of 14 high-dose arterial chemotherapy with hemoperfusion for 9 patients with advanced liver cancer. Materials and Methods: Administration route: 4 cases underwent interventional hepatic artery catheterization, 1 case underwent direct hepatic artery catheterization, and 4 cases underwent hepatic artery catheterization outside of subcutaneous drug pump. Drugs and doses: Mitomycin (10-30 mg, average 21.07), cisplatin (80-180 mg, mean 142.86), and 5-fluorouracil. Dialysis: 240 minutes, 200 ml/minute. Six patients were treated once, two were treated twice, and one was treated four times. Every 2 treatment gaps, the time is 28 to 56 days. Results: All patients were tolerated for treatment. No serious complications were found. There are 4 survivors, and the average survival time of death is August. One patient had complete remission (11%), two patients had partial remission (22%), 5 patients were stable (56%), and 1 patient progressed (11%). Conclusion: High-dose arterial chemotherapy combined with hemodialysis can be an effective palliative treatment for advanced cancer patients.