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目的分析新生儿持续肺动脉高压(PPHN)的临床和死亡相关因素,以利于进一步降低PPHN的病死率。方法分析40例PPHN患儿的临床资料。结果 40例患儿中死亡17例,病死率42.5%。羊水污染、酸中毒、肺动脉收缩压及各种并发症的发生可能是PPHN死亡的高危因素。结论新生儿PPHN病因复杂,治疗困难,病死率高。早期诊断、及时给予恰当的治疗可改善预后。
Objective To analyze the clinical and mortality related factors of neonatal persistent pulmonary hypertension (PPHN) in order to further reduce the mortality of PPHN. Methods The clinical data of 40 children with PPHN were analyzed. Results 40 cases of children died in 17 cases, the mortality rate of 42.5%. Amniotic fluid contamination, acidosis, pulmonary artery systolic pressure and the occurrence of various complications may be the risk factors for the death of PPHN. Conclusion Neonatal PPHN causes complex etiology, difficult treatment and high mortality. Early diagnosis, timely and appropriate treatment can improve the prognosis.