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目的探讨单纯性肥胖儿童血浆内脂素水平与相关因素的关系。方法2006年2月至2007年2月在天津医科大学总医院儿科内分泌门诊采用酶联免疫法测定50例单纯性肥胖儿童和30名正常对照的血浆内脂素。并分析血浆内脂素与收缩压、舒张压、体质量指数、体脂百分比、腰围、腰臀比及空腹血糖、空腹胰岛素水平、胰岛素抵抗指数、胰岛素敏感性指数及血脂的相关关系。结果(1)肥胖组血浆内脂素质量浓度为(32.26±6.83)μg/L,对照组为(25.69±8.05)μg/L,肥胖组明显高于对照组(P<0.01)。(2)内脂素与年龄、性别无相关关系;与体质量指数、体脂百分比、空腹血糖和胰岛素抵抗指数呈显著的正相关(相关系数r分别为0.333、0.301、0.486、0.290,P<0.01);与收缩压、舒张压、腰围、腰臀比、空腹胰岛素水平呈正相关(相关系数r分别为0.280、0.278、0.242、0.273、0.221,P<0.05);与胰岛素敏感性指数、高密度脂蛋白呈负相关(相关系数r分别为-0.269、-0.222,P<0.05);与总胆固醇、三酰甘油(甘油三酯)、低密度脂蛋白无相关关系。(3)多元逐步回归分析表明空腹血糖为影响内脂素最为显著的因素,标准化偏回归系数为0.486(P<0.01),R2=0.236。结论血浆内脂素水平与肥胖程度、脂肪分布、糖、脂代谢密切相关。初步提示内脂素可能与儿童肥胖的发生发展密切相关。
Objective To investigate the relationship between plasma visfatin and related factors in simple obesity children. Methods From February 2006 to February 2007, plasma visfatin was measured in pediatric endocrinology clinic of Tianjin Medical University General Hospital by enzyme-linked immunosorbent assay in 50 cases of simple obesity children and 30 normal controls. The relationship between plasma visfatin and systolic blood pressure, diastolic blood pressure, body mass index, body fat percentage, waist circumference, waist-hip ratio, fasting blood glucose, fasting insulin, insulin resistance index, insulin sensitivity index and blood lipids were analyzed. Results (1) The plasma visfatin concentration was (32.26 ± 6.83) μg / L in obesity group and (25.69 ± 8.05) μg / L in obesity group, but significantly higher in obesity group than in control group (P <0.01). (2) There was no correlation between visfatin and age and sex, but significant positive correlation with body mass index, body fat percentage, fasting blood glucose and insulin resistance index (r = 0.333,0.301,0.486,0.290, P < 0.01), but positively correlated with systolic blood pressure, diastolic blood pressure, waist circumference, waist-hip ratio, and fasting insulin levels (r = 0.280,0.278,0.242,0.273,0.221, P <0.05, respectively); with insulin sensitivity index (R = -0.269, -0.222, P <0.05, respectively), but not with total cholesterol, triglyceride (triglyceride) and low density lipoprotein. (3) Multiple stepwise regression analysis showed that fasting blood glucose was the most significant factor affecting visfatin, the standardized partial regression coefficient was 0.486 (P <0.01), R2 = 0.236. Conclusion Plasma visfatin levels are closely related to the degree of obesity, fat distribution, carbohydrate and lipid metabolism. Preliminary suggest that visfatin may be closely related to the occurrence and development of childhood obesity.