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抗生素８９－０７、庆大霉素、阿米卡星按每天５０、１００、１５０ｍｇ／ｋｇ，ｉｍ给予大鼠。分别于给药后５、１０、１５天处死动物，取样作肾功能和肾脏光镜形态学检查，比较评价了３种氨基糖苷类抗生素的肾脏毒性，ｉｍ庆大霉素１００ｍｇ／（ｋｇ·ｄ）以上剂量的动物，给药后７天就出现死亡，５０ｍｇ组随给药时间的延长，肾功能异常的指标逐渐增多，肾小管上皮细胞也由个别散在性的坏死发展到大片状和广泛性的严重坏死。抗生素８９－０７和阿米卡星５０ｍｇ组，仅见个别肾功能指标异常，肾小管上皮细胞仅见混浊肿胀等变性，即使是１００ｍｇ组的肾小管上皮细胞坏死的程度也没有庆大霉素５０ｍｇ组严重。上述结果表明，抗生素８９—０７的肾毒作用明显比庆大霉素轻。
Antibiotics 89-07, gentamicin, amikacin were administered to rats at 50, 100, 150 mg / kg, im daily. Animals were sacrificed on days 5, 10 and 15 after administration, respectively. The samples were taken for renal function examination and morphological examination by light microscope. The renal toxicity of three aminoglycoside antibiotics was compared and evaluated. Im gentamicin 100 mg / (kg · d ) Above the dose of the animals, died after 7 days of administration, 50mg group with the extension of time, indicators of renal dysfunction gradually increased, renal tubular epithelial cells also developed from individual scattered necrosis to large flake and extensive Serious necrosis. Antibiotics 89-07 and amikacin 50mg group, only to see the individual renal dysfunction, renal tubular epithelial cells only see turbid swelling and other degeneration, even the 100mg group of tubular epithelial cell necrosis is not the degree of severe gentamicin 50mg group . The above results show that the nephrotoxicity of antibiotic 89-07 is significantly lighter than gentamicin.