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目的探讨血清内脂素水平与妊娠期糖尿病(GDM)患者糖代谢的关系。方法80例孕妇被分为GDM组和对照组,分别检测其Visfatin、空腹胰岛素(FIN)、空腹血糖(FBG)及服糖后1h、2h、3h血糖(1hPG、2hPG、3hPG)水平,计算胰岛素抵抗指数(HOMA-IR)。结果(1)GDM组visfatin、FPG、1hPG、2hPG、3hPG、HOMA-IR、FIN水平明显高于对照组(P<0.01)。(2)GDM组血清内脂素水平与HOMA-IR、2hPG均有明显相关性(P均<0.01)。多元线性逐步回归分析表明,2hPG是影响血清内脂素的独立相关因素。结论GDM患者血清内脂素水平升高,可能是机体针对GDM患者体内血糖增高所发生的一种代偿效应。
Objective To investigate the relationship between serum visfatin and glucose metabolism in patients with gestational diabetes mellitus (GDM). Methods 80 pregnant women were divided into GDM group and control group. The levels of Visfatin, fasting insulin (FIN), fasting blood glucose (FBG) and 1h, 2h and 3h postprandial blood glucose (1hPG, 2hPG and 3hPG) Resistance index (HOMA-IR). Results (1) The levels of visfatin, FPG, 1hPG, 2hPG, 3hPG, HOMA-IR and FIN in GDM group were significantly higher than those in control group (P <0.01). (2) Serum visfatin levels in GDM group were significantly correlated with HOMA-IR and 2hPG (all P <0.01). Multivariate linear stepwise regression analysis showed that 2hPG was an independent factor affecting serum visfatin. Conclusions Elevated serum visfatin levels in GDM patients may be a compensatory effect for the increase of blood glucose in GDM patients.