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目的：探讨高原低氧环境下血管内皮细胞（ＶＥＣ）的损伤情况及功能变化；方法：对从平原（海拔１ ４００ｍ ）进驻海拔３ ７００ｍ （１０ 人）与５ ３８０ｍ （２０ 人）高原第７ 天和半年的青年进行循环内皮细胞计数（ＣＥＣ）、血浆内皮素－１（ＥＴ－１）和心钠素（ＡＮＰ）含量测定，并与平原作对照。结果：在高原缺氧条件下，血浆ＣＥＣ计数和ＥＴ－１、ＡＮＰ含量明显高于平原（Ｐ＜ ０．０１），且随海拔高度的升高而增高（Ｐ＜ ０．０１），初入高原时明显高于在高原居住半年的数值（Ｐ＜ ０．０５ 或Ｐ＜ ０．０１）。在不同海拔高度居住不同时间的ＥＴ－１与ＣＥＣ和ＡＶＰ呈高度正相关；结论：血管活性肽ＥＴ－１、ＡＮＰ分泌可能对急、慢缺氧环境下的心血管系统功能及神经内分泌调节具有重要意义。
Objective: To investigate the damage and functional changes of vascular endothelial cells (VECs) under plateau hypoxic environment.METHODS: The changes of vascular endothelial cells (VECs) injury and platelet function were observed in the plateau (elevation 1,400m) at 7 700m (10 persons) and 5 380m (20 persons) (CEC), plasma endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) were measured and compared with those of the plain. Results: The levels of CEC, ET-1 and ANP were significantly higher in the anaerobic plateaus than those in the plains (P <0.01), and increased with altitude (P <0.01) The plateau was significantly higher than that in the plateau for six months (P <0.05 or P <0.01). ET-1 and CEC were significantly correlated with AVP at different altitudes; Conclusion: The secretion of ET-1 and ANP of vasoactive peptides may have effects on cardiovascular system function and neuroendocrine regulation under acute and hypoxic conditions Significance.