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近年对于药物相互作用的兴趣日增,而有关药物与口服甾体避孕药相互作用的描述则是较近的事。这可能和早先使用者服用雌激素、孕激素量超过必需的高剂量有关。当炔雌醇剂量降到每天50μg或更低时,开始注意到其他药物可能影响口服甾体避孕药的效果问题。现在认识到,某些避孕失败乃由药物相互作用所致。一、其他药物对甾体避孕药的影响:1971年发现一些同时进行抗结核治疗的口服甾体避孕药妇女经间期出血率较高。之后,把镇痉药、抗菌素、止痛剂及作用中枢神经系统药物也与避孕失败联系起来。必须指出,将某类避孕药剂的结果引伸到另一类避孕药中去是错误的;而且,药物相互作用的个体差异又很大。此外,随着含炔雌醇剂量更低的避
Interest in drug interactions has been increasing in recent years, and the description of the interaction of drugs with oral steroid contraceptive pills is more recent. This may be related to previous users of estrogen, the amount of progestin over the necessary high dose. When the ethinyl estradiol dose dropped to 50 μg per day or less, attention began to be paid to the effect that other medications might have on oral steroid contraceptives. It is now recognized that some contraceptive failures result from drug interactions. First, the impact of other drugs on steroidal contraceptives: In 1971, some women with oral steroid contraceptives who received anti-TB treatment were found to have a higher rate of inter-period bleeding. Later, antispasmodics, antibiotics, analgesics and central nervous system drugs were also linked to contraceptive failure. It must be pointed out that it is a mistake to extend the results of one type of contraceptives to the other, and that individual differences in drug interactions are significant. In addition, with ethinylestradiol dose lower avoidance