脑内γ-氨基丁酸水平对学习记忆的影响(摘要)

• 作 者: 张士善 陈醒言
• 出 处: 温州医学院学报
• 发表日期: 1991年02期
• 关键词: 氨氧乙酸 γ-氨基丁酸 跳台法 盐酸氨基脲 脑室内注射 损害作用 拮抗 摘要 樟柳碱 负性调节

本文采用小鼠跳台法,于训练前3分钟先在脑室内注射γ-氨基丁酸(GABA)0.1μg,或1.5小时前腹腔注射氨氧乙酸20mg/kg,以提高脑内GABA水平,对记忆获得均有明显损害作用。GABA和氨氧乙酸合用有明显协同。然而,于训练前3.5小时先腹腔注射盐酸氨基脲110mg/kg,以降低脑内GABA水平,对樟柳碱造成的记忆获得不良则有明显改善作用。当氨基脲与GABA合用时表现轻度拮抗。以上结果表明脑内GABA水平提高对于学习记忆有负性调节作用。

In this study, mice were challenged by the step-down method in mice. GABA 0.1 μg was intracerebroventricular injected in the first 3 minutes before training or intraperitoneal injection of 20 mg / kg of L-AA was given 1.5 hours before to improve the brain GABA level, Obviously have a detrimental effect. There is a clear synergy between GABA and Aminoxyacetate. However, intraperitoneal injection of semicarbazide hydrochloride 110 mg / kg ip 3.5 hours prior to training reduced brain GABA levels and markedly improved memory impairment of anisodine. Squalane showed mild antagonism when combined with GABA. The above results show that the increase of brain GABA has a negative regulation on learning and memory.