论文部分内容阅读
由于眼部解剖生理及物理屏障的存在，滴眼液的眼部低生物利用度已成为影响药物治疗效果最大因素。药物递送系统可通过延长药物在眼表的停留时间以及增加药物透角膜能力，实现减少给药次数、维持有效治疗浓度的目的，成为当前眼科改善药物眼部生物利用度的研究热点。本文总结了近十年眼表药物递送系统的发展，主要介绍了纳米结构、环糊精及其衍生物、凝胶、角膜接触镜这些体系作为药物载体的优缺点及进展，认为各类眼表药物递送体系利用各自的特点可在一定程度上提高药物的眼部生物利用度，但在可实际临床应用前仍存在相应的问题需要解决。“,”Due to the anatomical and physical barriers, the low bioavailability of eye drops has become the primary problem in optimizing efficacy.Drug delivery system can reduce administration frequency and keep the therapeutic concentration while increasing ocular surface retention time and strengthening ability to permeate the cornea.Therefore, many ophthalmologists and relevant scientists focus on the ocular surface drug delivery system to overcome the drawback of low bioavailability.The advances of drug delivery system in ocular surface in the past decade were reviewed to give an introduction about the advantages and disadvantages as well as advances of nano-constructions, cyclodextrin and its derivatives, gels and contact lens.It is expected that ocular surface drug delivery systems could enhance the bioavailability to some extent, and have a good prospect in clinical practice when existing problems handled.