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为研究蓝刺头及蓝刺头复方水提物对Ⅱ型糖尿病(T2DM)大鼠血糖、血脂的影响。本试验以SD大鼠饲喂高脂高糖饲料加小剂量链脲佐菌素(STZ)腹腔注射的方法建立T2DM大鼠模型。将大鼠随机分为正常对照组,模型组,蓝刺头水提物高、中、低浓度组,蓝刺头复方水提物高、中、低浓度组,对各组大鼠分别连续56d灌服生理盐水及相应浓度蓝刺头及蓝刺头复方水提物,并检测大鼠相关血糖血脂生化指标。结果显示,蓝刺头及蓝刺头复方水提物高、中剂量组对Ⅱ型糖尿病大鼠空腹血糖均呈明显升高趋势(P<0.05);蓝刺头及蓝刺头复方低剂量组对Ⅱ型糖尿病大鼠空腹血糖均无明显的改善;蓝刺头及蓝刺头复方水提物高、中、低剂量组均可明显降低TC、TG和LDL-C的含量(P<0.05),HDL-C无明显差异(P>0.05)。结果表明,蓝刺头及蓝刺头复方水提物对实验性Ⅱ型糖尿病大鼠具有降糖、降脂的作用。
To investigate the effects of blue prickly head and blue prickly stem aqueous extract on blood glucose and blood lipid in type 2 diabetes mellitus (T2DM) rats. In this study, SD rats were fed with high-fat, high-sugar and low-dose streptozotocin (STZ) intraperitoneal injection method to establish T2DM rat model. The rats were randomly divided into normal control group, model group, high, medium and low concentration of blue prickly head water extract, high, medium and low concentration of blue prickly stem aqueous extract, Irrigation with saline and the corresponding concentration of blue prickly and blue prickly head compound aqueous extract, and the detection of blood glucose and blood lipid-related biochemical indicators. The results showed that the fasting blood glucose of type Ⅱ diabetic rats increased significantly (P <0.05) in the high and medium dose groups of blue and blue prickly stem aqueous extract, Fasting plasma glucose in type 2 diabetic rats showed no significant improvement. The contents of TC, TG and LDL-C in high, medium and low dose groups of blue-tailed head and blue-tailed head aqueous extract significantly decreased (P <0.05) , HDL-C no significant difference (P> 0.05). The results showed that the aqueous extract of blue prickly head and blue prickly head compound had a hypoglycemic and hypolipidemic effect on experimental type 2 diabetic rats.