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近年来对阴道环的药代动力学和药效学研究表明,使用释放左旋18甲(LNG)20μg/24hr阴道环妇女的不规则出血发生率较释放炔诺酮(NET)200μg/24hr阴道环妇女的低,而抑制排卵率前者为48%,后者为75%。根据以前研究结果,放环90天内每天LNG消失率为0.3%,即90天时减少LNG总量的25%。说明其避孕效果长于90天,可达1年,本文报告了10名健康妇女应用释放LNG20μg/24hr阴道环1年期间血中LNG水平,以及LNG水平与性激素结合球蛋白(SHBG)间的关系。受试者参与研究前至少有3个正常月经周期(26～35天),至少3个月未用甾体类避孕药或宫内节育器,平均年龄为32.9岁(25～36岁)。释放LNG的阴道环用多聚二甲基硅氧烷硅橡胶制成,芯内含LNG20mg,预期体内释放率为LNG20μg/24hr,
In recent years, studies on the pharmacokinetics and pharmacodynamics of the vaginal rings have shown that the incidence of irregular bleeding in women receiving vaginal ring 20 μg / 24 hr in the release of levonorubicin 18 (LNG) is 200 μg / 24 hr more than that in releasing norethindrone (NET) Women’s low, while the inhibition of ovulation rate was 48% for the former, the latter was 75%. According to the results of the previous study, the daily LNG disappearance rate was 0.3% within 90 days of releasing the ring, that is, 25% of the total LNG was reduced at 90 days. The result shows that the contraceptive effect is longer than 90 days and up to 1 year. The paper reports the LNG level in blood and the relationship between LNG level and sex hormone binding globulin (SHBG) in 10 healthy women during one year of release of 20μg / 24hr LNG. Subjects had at least 3 normal menstrual cycles (26-35 days) prior to participating in the study, with no steroidal contraceptives or IUDs for a minimum of 3 months, with an average age of 32.9 years (25-36 years). Vaginal ring releasing LNG made with polydimethylsiloxane silicone rubber, the core containing LNG 20mg, the expected rate of in vivo release of LNG20μg / 24hr,