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607例门诊老年功能性消化不良患者随机分为治疗组和对照组.治疗组(317例)中po西沙比利5mp tid×4wk;对照组(290例)po多福立酮10mgtid×4wk.结果:西沙比利对餐后饱胀、上腹胀满、恶心及呕吐等症状的缓解作用明显优于多潘立酮(P<0.01).治疗组总有效率为86.1%,对照组为77.6%,差异有显著性.西沙比利的主要不良反应为腹泻、肠鸣和腹痛,但患者可以耐受.结果表明西沙比利对老年人功能性消化不良有良好的疗效.
607 cases of outpatients with functional dyspepsia were randomly divided into treatment group and control group.Purplexapril 5mp tid × 4wk in the treatment group (317 cases) and poofoldone 10mgtid × 4wk in the control group (290 cases) : The effect of cisapride on relieving symptoms such as postprandial fullness, fullness of upper abdomen, nausea and vomiting was significantly better than that of domperidone (P <0.01) .The total effective rate was 86.1% in treatment group and 77.6% in control group, the difference was significant The major adverse effects of cisapride were diarrhea, bowel and abdominal pain, but patients were well tolerated.The results showed that cisapride had a good effect on functional dyspepsia in the elderly.