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用一个非天然四元环氨基酸（Ｓ）－２－吖啶酮－４－羧酸取代ＴＲＨＮ－端的五元环焦谷氨酸，用液相法合成了一个新的ＴＲＨ类似物ＹＭ－１４６７３。经质谱、元素分析和层析行为确定产品为纯品。
A novel TRH analogue YM-14673 was synthesized by liquid-phase method using a nonnatural 4-membered cyclic amino acid (S) -2-acridone-4-carboxylic acid instead of TRHN-terminal 5-membered ring pyroglutamic acid. By mass spectrometry, elemental analysis and chromatographic behavior to determine the product is pure.