论文部分内容阅读
为探讨慢性淋巴性甲状腺炎 (桥本病 )的早期诊断 ,我们对临床综合判断和随诊明确诊断的 74例桥本病患者 ,应用放射免疫法测定循环血中甲状腺激素和相应自身抗体。结果发现 ,早期时FT4 、FT3明显高于正常对照组 ,阳性率分别为 90 5%和 4 5 9% ;TT3和TT4 升高者不及FT3、FT4 ,仅为 2 4 3 %和3 6 5% ;TG Ab及TM Ab升高分别为 4 3 2 %和 3 2 4 % ,滴度分别为 3 6 1 %～ 4 5 3 %及 2 8 3 %～ 4 6 1 % ;TSH、rT3浓度如常。随着病程发展 ,经 1 2～ 3 6个月后 ,2 1例呈甲减症 ,血激素浓度TSH值升高 ;FT3及FT4 降低 ,TG Ab和TM -Ab滴度上升。若循环血中甲状腺激素值升高 ,无明显甲亢症状 ,而S -TSH正常 ,应疑及本病。在监测病情发展过程中若有TSH浓度升高 ,而甲状腺激素水平正常 ,此时要特别注意存在亚临床性甲减和甲减
In order to explore the early diagnosis of chronic lymphatic thyroiditis (Hashimoto’s disease), 74 cases of Hashimoto’s disease who were diagnosed clinically and diagnosed clinically were enrolled. Thyroid hormone and corresponding autoantibodies were measured by radioimmunoassay. The results showed that FT4 and FT3 in the early stage were significantly higher than those in the normal control group, the positive rates were 90.5% and 45.9% respectively. The elevated levels of TT3 and TT4 were less than those of FT3 and FT4 (only 23.4% and 36.5% The levels of TG Ab and TM Ab were 43.2% and 32.4% respectively, with titers of 361% -453% and 283% -461%, respectively. The concentrations of TSH and rT3 were normal. As the course of development, after 1-22 months, 21 cases showed hypothyroidism, serum TSH value increased; FT3 and FT4 decreased, TG Ab and TM -Ab titers increased. If the circulating blood thyroid hormone value, no obvious symptoms of hyperthyroidism, and S -TSH normal, should be suspect and the disease. In monitoring the progression of the disease if TSH concentrations, and thyroid hormone levels are normal, this time with special attention to the existence of subclinical hypothyroidism and hypothyroidism