论文部分内容阅读
目的:分析莲必治注射液不良反应的临床表现,为临床安全用药提供参考。方法:利用万方医药数据镜像系统和中国知网检索1999～2010年国内医学期刊,搜集莲必治注射液不良反应病例进行回顾性分析。结果:检索获得莲必治注射液不良反应文献20篇,病例148例,因累及多个系统,不良反应194例次,其中严重不良反应8例次。泌尿系统损害73例次,占37.63%;过敏反应86例次,占44.33%。过敏反应多发生在给药后2～90min,泌尿系统损害多发生在用药后30min～5d。148例不良反应中联合用药102例,占68.9%,单用莲必治注射液46例,占31.1%。结论:莲必治注射液不良反应主要表现为急性肾损害和过敏反应,临床应用时应详细询问患者的药物过敏史以及个人和家族疾病史,严格掌握适应证,按照药品说明书的规定,严格控制药物输液的浓度和速度。应避免不必要的联合用药。
Objective: To analyze the clinical manifestations of adverse reactions of Lianbizhi injection and provide a reference for clinical safety. Methods: Using Wanfang Medical Data Mirroring System and Chinese Knowledge Network to search the domestic medical journals from 1999 to 2010, the adverse reactions of Lianbzhi Injection were collected and retrospectively analyzed. Results: 20 literatures about adverse reactions of Lianbhibie injection were retrieved. Among 148 cases, 194 cases were involved in adverse reactions because of multiple systems involved. Among them, 8 cases were serious adverse reactions. Urinary system damage 73 cases, accounting for 37.63%; 86 cases of allergic reactions, accounting for 44.33%. Allergic reactions occurred in 2 to 90min after administration, urinary system damage occurred in 30min ~ 5d after treatment. A total of 148 adverse reactions were combined with 102 cases (68.9%), and Lianbzhi Injection alone (46 cases), accounting for 31.1%. Conclusion: The adverse reactions of Lianbizhi injection are mainly acute renal damage and anaphylaxis. In clinical application, patients should be asked about the history of drug allergy and personal and family history of diseases in detail. The indications should be strictly controlled, and strictly controlled according to the instruction manual Drug infusion concentration and speed. Avoid unnecessary combination therapy.