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目的 探讨嗅神经母细胞瘤的临床特征、治疗方法及预后, 争取提高诊断率及疗效。方法 回顾分析1992~2002年我院收治的17例嗅神经母细胞瘤患者的临床资料。根据Kadish分期A期1 例、B期7 例、C期9例。单纯手术1例、单纯化疗3例、单纯放疗6 例、手术加放疗7 例。大部分病人放疗剂量DT60Gy~72Gy。结果 本组病人5年生存率为35 2% (6/17), 其中A期100% (1/1)、B期42 9% (3/7)、C期22 2% (2/9);单纯手术或单纯化疗1年局控率为0, 单纯放疗5年生存率为33 3% (2/6), 综合治疗5 年生存率42 9% (3/7),早期(A、B期) 患者的5年生存率好于晚期患者(C期)。结论 嗅神经母细胞瘤对放疗较敏感, 早期治疗及以手术和放疗为主的综合治疗对提高疗效尤为重要。
Objective To investigate the clinical characteristics, treatment and prognosis of olfactory neuroblastoma, and to improve the diagnosis rate and curative effect. Methods The clinical data of 17 patients with olfactory neuroblastoma who were admitted to our hospital from 1992 to 2002 were retrospectively analyzed. According to Kadish stage A in 1 case, B in 7 cases, C in 9 cases. Simple surgery in 1 case, simple chemotherapy in 3 cases, simple radiotherapy in 6 cases, surgery plus radiotherapy in 7 cases. The majority of patients radiotherapy dose DT60Gy ~ 72Gy. Results The 5-year survival rate was 35 2% (6/17) in this group, of which 100% (1/1) in stage A, 42.9% (3/7) in stage B and 22.2% (2/9) in stage C ; The rate of 5-year radiotherapy alone was 33 3% (2/6), and the 5-year survival rate was 42 9% (3/7) in the simple operation or chemotherapy alone. ) Patients have better 5-year survival than patients with advanced disease (C). Conclusion Olfactory neuroblastoma is more sensitive to radiotherapy. Early treatment and comprehensive treatment based on surgery and radiotherapy are especially important to improve the curative effect.