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A mineral resource zone, rich in resources and energy, is intensively developed and disturbed by human activities, which causes an obvious change of landscapes. Taking Wu’an of Hebei Province, China, as a case study, this paper extracts landscape information of mineral resource zones through overlapping mineral resources distribution map and landscape patt map. And then, various landscape indices are selected for analyzing the effects of grain size (30, 60, 90, 120, 150, 180, 210, 240, 270 and 300 m) on landscape patts. Due to different kinds of landscape information transmitted by indices, the changing trends vary with the increase of grain sizes. Accordingly the landscape indices are classified into three types of effects:disturbance, continuity and sustainability, and each type of effect has its own optimal range for grain sizes. Then the optimal range of grain size on landscape patts in mineral resource zones is gained through a comparison of the effects in various grain sizes of landscape indices. The best first domain of scale covers 30–90 m, with a suitable grain size of 30–60 m before intensive mining and a suitable grain size of 60–90 m after intensive mining. Besides, the suitable grain sizes for reflecting disturbance, continuity and sustainability before intensive mining are 30–60, 30–60 and 30–90 m, respectively, however, the sizes are changed to 60–90, 60–90 and 30–90 m, respectively, after intensive mining. The results are helpful for rational land use and optimal landscape allocation.