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目的调查百日咳聚集性发病的传播方式,为预防和控制百日咳提供依据。方法现场调查病例及密切接触者,鼻咽拭子采用套式聚合酶链反应检测百日咳鲍氏杆菌DNA,血液标本采用酶联免疫吸附试验检测抗百日咳鲍氏杆菌特异毒素IgG和IgM抗体。结果此次百日咳家庭聚集性发病的传播方式为成年人→婴幼儿→成年人。结论成年人在百日咳的传播中具有重要的流行病学意义,同时应加强对百日咳病例密切接触者的主动监测。
Objective To investigate the mode of transmission of pertussis pertussis disease and provide a basis for the prevention and control of whooping cough. Methods Field investigation of cases and close contacts, Nasopharyngeal swabs were used to detect the DNA of Bordetella pertussis using nested polymerase chain reaction. Antibodies against B. pertussis specific toxins IgG and IgM were detected in blood samples by enzyme-linked immunosorbent assay. Results The prevalence of pertussis familial transmission was from adult to infancy to adult. Conclusion Adults have significant epidemiological implications for the transmission of whooping cough and should be more active in monitoring close contacts of pertussis patients.