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作者通过新生儿剖检病例的心脏分层环切切片研究,选出新生儿心肌坏死病例,搞清了其病理所见与临床所见的关系。对象与方法以解剖学定为心脏构造正常的未成熟儿、疾病新生儿89例为对象,依据病理所见将其分为正常心肌、心肌缺血性病变、心肌坏死病变3组,将心肌有明显坏死性病变的16例定为心肌坏死组,并应用抗肌红蛋白抗体作免疫组织学研究。从心肌正常的44例中选出16例相当于心肌坏死组的怀孕周数、出生体重为正常心肌组,研究其临床项目,并探讨其病理生理。结果病理所见:心肌坏死为局限性或广泛地图状病变。该部位心肌纤维细胞质呈均匀深桃红色,横纹消失,核浓缩或消失。心肌坏死呈多中心性不规则分布,通常为两心室。即与冠状动脉流域不尽一致。心肌坏死的好发部位为乳头肌或心内膜下。
By neonatal cardiac autopsy cases of the heart of the ring cut section of the study, selected neonatal myocardial necrosis cases, to find out the pathology and clinical findings. Subjects and Methods Anatomical anatomy as the normal immature children, newborn disease in 89 cases as the object, according to the pathological findings will be divided into normal myocardium, myocardial ischemic lesions, myocardial necrosis lesions in three groups, the myocardial Sixteen cases of obvious necrotic lesions were defined as myocardial necrosis group, and anti-myoglobin antibody was used for immunohistological study. From the normal 44 cases of myocardium, 16 cases were selected as corresponding to the number of gestational weeks in myocardial necrosis group, and the birth weight was normal myocardial group. The clinical items were studied and their pathophysiology was discussed. Results Pathology seen: myocardial necrosis as a localized or extensive lesion. The area of myocardial fibrosis cytoplasm showed a dark pink, horizontal stripes disappear, nuclear condensation or disappear. Myocardial necrosis showed multicentric irregular distribution, usually two ventricle. That is not consistent with the coronary artery. The main site of myocardial necrosis papillary muscle or subendocardial.