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残杀威原药及其乳油具有中等度急性经口吸入毒性和轻度经皮毒性。一次经口染毒引起全血胆碱酯酶(ChE)抑制的阈剂量为11mg/kg。受试物对小鼠无明显蓄积作用;对大鼠未见胚胎毒性和致畸作用;Ames试验、小鼠骨髓细胞和生殖细胞染色体畸变试验均阴性。大鼠亚慢性吸入残杀威蒸气和烟雾的无作用浓度为6.8mg/m~3。因此建议生产车间的残杀威容许浓度一时间加权均值为03.5mg/m~3,短时间接触限值为2.0mg/m~3。
Propoxur and the EC have moderate acute oral toxicity and mild dermal toxicity. A threshold dose of 11 mg / kg of whole blood cholinesterase (ChE) inhibition caused by a single oral dose was obtained. The test substance had no significant accumulation effect on mice; no embryotoxicity and teratogenic effect on rats; Ames test, mouse bone marrow cells and germ cell chromosome aberration test were negative. Sub-chronic inhalation of rats vapors and smoke non-effect concentration of 6.8mg / m ~ 3. Therefore, it is suggested that the allowable concentration of propoxides in the production plant should be weighted at a time of 03.5 mg / m 3 and the short-term exposure limit of 2.0 mg / m 3.