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目的：明确参与创伤失血性休克的发病过程的亚型阿片受体。方法：观察创伤失血性休克后大鼠心脏μ、δ和κ阿片受体的变化及与血流动力学指标变化的关系；观察δ和κ阿片受体特异性拮抗剂对创伤失血性休克大鼠血流动力学指标的影响。结果：创伤失血休克后，大鼠心脏δ和κ阿片受体数目明显升高，与血流动力学指标下降呈显著负相关。δ和κ阿片受体特异性拮抗剂可明显逆转创伤失血休克大鼠血流动力学指标的下降。结论：心脏δ和κ阿片受体可能参与了创伤失血性休克的发病过程。
OBJECTIVE: To identify subtypes of opioid receptors involved in the pathogenesis of traumatic hemorrhagic shock. Methods: The changes of μ, δ and κ opioid receptors in rat heart after traumatic hemorrhagic shock were observed and the relationship between the changes of hemodynamics and the changes of hemodynamics was observed. The effects of δ and κ opioid receptor antagonists on traumatic hemorrhagic shock rats Effects of hemodynamic parameters. Results: After traumatic hemorrhagic shock, the number of δ and κ opioid receptors in rat heart increased significantly, which was negatively correlated with the decline of hemodynamics. δ and κ opioid receptor specific antagonists can significantly reverse the traumatic hemorrhagic shock hemodynamics decline. Conclusion: The cardiac δ and κ opioid receptors may be involved in the pathogenesis of traumatic hemorrhagic shock.