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目的分析和评价上海市南汇区“筛检-干预”卒中一级预防策略实施3年的潜在利益。方法在全区69.7万框架人群中选择≥35岁具有卒中危险因素暴露的人群进行脑血管血流动力学指标(CVHI)检测,筛选出18271人CVHI积分值<70分的卒中高危个体,根据知情同意原则分成药物干预组(10313人)和对照组(7958人),实施3年干预和随访卒中发病。计算每预防1例卒中需要筛检的人数(NNS)和需要治疗的人数(NNT)。结果针对筛检出的高危个体实施全部干预方案的NNS为148,根据知情同意原则实施部分干预方案的NNS为268。干预策略实施3年的NNT为51。结论“筛检-干预”卒中一级预防策略实施3年后可取得良好的效益。
Objective To analyze and evaluate the potential benefits of “screening-intervention” primary prevention strategies in Nanhui District for 3 years. Methods A total of 697,000 people in the whole district were enrolled in this study. CVHI was used to detect the risk of stroke in those aged 35 years and 18271 subjects with high risk of CVHI score <70 were screened. According to the information The principle of consent was divided into drug intervention group (10313) and control group (7958), and 3-year intervention and follow-up stroke. Calculate the number of people requiring screening (NNS) and the number of people requiring treatment (NNT) for each stroke that was prevented. Results The NNS for all interventions screened for high-risk individuals was 148, and 268 for some interventions based on the principle of informed consent. The NNT for the three-year intervention strategy is 51. Conclusion The three-year prevention and cure strategy of “screening-intervention” can achieve good results.