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作者发现在胸腺基质细胞上清液中有集落刺激因子样因子存在,以粒-巨噬细胞集落刺激因子为主.此外,还测到了白细胞介素1样因子,在其总核糖核酸中还测得白细胞介素6、白细胞介素7的转录.以上这些结果提示:胸腺基质细胞在淋巴细胞发育过程中是一个多能成分,所分泌的细胞因子对淋巴细胞的分化起调节作用。同时.该上清液对经2、4、8、10GyX射线全身照射后的小鼠胸腺细胞脱氧核糖核酸合成有促进作用,说明胸腺基质细胞对辐射损伤的淋巴细胞亦有修复作用。
The authors found that there are colony-stimulating factor-like factors in the thymus stromal cell supernatant, which are mainly granulocyte-macrophage colony-stimulating factor. In addition, interleukin-1-like factors were measured, and transcript levels of interleukin-6 and interleukin-7 were also measured in their total RNA. These results suggest that: thymocytes in the development of lymphocytes is a pluripotent component of the secretion of cytokines on lymphocyte differentiation play a regulatory role. Simultaneously. The supernatant on the 2, 4, 8, 10 Gy X-ray irradiation of mouse thymocyte DNA synthesis has a role in promoting thymic stromal cells on radiation-injured lymphocytes also repair.