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目的选择萘普待因片的生产工艺。方法对处方中药物进行分析,查找文献来确定萘普待因片的赋形剂、制粒时的混合方法及颗粒干燥温度;用正交试验法,以磷酸可待因、萘普生的溶出度为指标,考察崩解剂及其加入方法、粘合剂、润滑剂对溶出度的影响。结果萘普待因片的最佳生产工艺为:取磷酸可待因与低取代羟丙纤维素混匀.再按等量递加混合法与萘普生混匀,加蒸馏水适量制粒,50～70℃干燥,加入硬脂酸镁,混匀,压片。结论该工艺科学合理。
The purpose of selecting naproxen tablets production process. Methods The prescription drugs were analyzed and the literature was searched to determine the excipients of naproxen tablets, the mixing method and the pellet drying temperature during granulation. The orthogonal test was used to determine the dissolution rate of codeine, naproxen Degree as an indicator to examine the disintegrating agent and its addition method, adhesive, lubricant on the dissolution rate. Results The optimal production process of naproxen tablets was as follows: mix codeine phosphate with low-substituted hydroxypropylcellulose, mix evenly with naproxen, and add appropriate amount of distilled water, 50 ~ 70 ℃ drying, adding magnesium stearate, mixing, tabletting. Conclusion The process is scientific and rational.