论文部分内容阅读
关于输精管粘堵节育,目前已有许多报道。然而目前使用的各种粘堵剂虽能达到避孕目的,但作用不能维持长久。其关键问题在于:粘堵剂注入后,粘堵部位的输精管管壁逐渐变薄,而管腔则逐渐扩大,导致紧贴管壁的粘堵物松动,使精子能从其间流过,最后致使避孕失败。采用酸性聚合物作为粘堵剂不仅能阻止精子通过,且能降低作用部位及附近的液体的pH值。电镜观察结果表明:当精子接近聚合物及其附近的酸性环境时,其头部的完整性便遭到破坏。本研究进一步证实:聚合物能影响精子头部的顶体酶和透明质酸酶。本文的实验使用新型粘堵剂——苯乙烯-顺丁烯二酐(SMA),目的在于研究长期粘堵的可能性,并观察当精子开始出现于精液内时,其避孕作用的维持状况。
On the vas deferens stuck blocking, there have been many reports. However, various sticking agents currently used to achieve the purpose of contraception, but the role can not be maintained for a long time. The key problem is that after the viscosifying agent is injected, the wall of the vas deferens at the viscous blocking site gradually becomes thinner while the lumen is gradually enlarged, which leads to the loosens of clogged objects close to the wall so that the spermatozoon can flow through it and finally causes Contraception failed. The use of acidic polymers as blocking agents can not only prevent sperm from passing through, but also reduce the pH of the liquid at and near the site of action. Electron microscopy observations show that when the sperm approaches the acidic environment of the polymer and its vicinity, the integrity of the head is destroyed. This study further confirms that polymers can affect acrosin and hyaluronidase in the sperm head. The purpose of this study was to investigate the possibility of long-term clogging and to observe the maintenance of contraception when sperm began to appear in the seminal fluid.