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目的探讨TCF7L2基因rs290487多态位点在云南昆明汉族人群中与2型糖尿病的相关性。方法采用套式PCR产物直接测序法对昆明汉族健康组94例,2型糖尿病组200例rs290487多态位点进行检测。结果云南昆明汉族人群rs290487三个基因型CC、CT和TT在病理组与对照组的频率分别为14%/6.4%、41.5%/46.8%和44.5%/46.8%。最少等位基因频率C在对照组与病理组为34.7%/29.8%,与2型糖尿病有趋势上的相关性,但差异无统计学意义(P>0.05)。结论TCF7L2基因rs290487在昆明汉族人群中与2型糖尿病无相关性。
Objective To investigate the association of rs290487 polymorphism of TCF7L2 gene with type 2 diabetes in Kunming, Yunnan Province. Methods Totally 94 cases of Kunming healthy Han nationality and 200 cases of type 2 diabetes mellitus were detected by nested PCR product direct sequencing. Results The frequency of CC, CT and TT genotypes of rs290487 in Kunming Han ethnic population was 14% / 6.4%, 41.5% / 46.8% and 44.5% / 46.8% respectively in the pathological group and the control group. The frequency of the allele C was 34.7% / 29.8% in the control group and pathology group, which showed no significant difference with type 2 diabetes (P> 0.05). Conclusion There is no correlation between TCF7L2 gene rs290487 and type 2 diabetes in Kunming Han population.