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尽管早在1929年Cannon 就指出情绪障碍可以通过中枢神经系统引起植物神经功能紊乱,进而导致胃肠道功能异常。但正如Myren 在“消化道溃疡的自然史——80年代新观点”一文中所指出那样,在消化道溃疡的危险因素中,精神因素同遗传、吸烟、某些药物刺激、单纯疱疹感染一样,尚缺乏统一的、令人信服的结论。我国几个大规模上消化道溃疡流行学调查资料展示以精神刺激为诱因者占全部病人的5.4～20.5%,其数字范围之大正反映了Myren 的观点。然而这种不统一也正是学者们感兴趣和不停探索的原因所在。
Although as early as 1929 Cannon pointed out that mood disorders can cause autonomic dysfunction through the central nervous system, leading to gastrointestinal dysfunction. But as Myren points out in “The Natural History of Gastrointestinal Ulcers - A New Perspective in the 1980s,” mental factors are at the same level as hereditary, smoking, some drug-induced, and herpes simplex infections among the risk factors for peptic ulcer disease, There is a lack of uniform and convincing conclusions. Several large-scale epidemiological survey of upper gastrointestinal ulcers in China showed that mental stimulation as a contributing factor accounted for 5.4% to 20.5% of all patients. The large number range reflects Myren’s point of view. However, this inconsistency is the reason why scholars are interested and keep exploring.