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代谢正常肥胖(MHO)是近年来备受关注的一类肥胖亚群,以肥胖但高胰岛素敏感性为特征,占肥胖群体的20%～30%。由于某些保护机制存在,MHO人群与以往所说的“高危肥胖”人群,在临床表现、炎症、代谢谱、治疗及预后等方面均截然不同,深入探索其代谢保护机制及临床参数的纵向变化对肥胖研究和卫生保健工作意义重大。本文从流行病学、界定标准、保护机制、研究前景等方面全面概括MHO的研究进展,旨在推进科研及临床工作者对这一重要肥胖亚型的认识。
Metabolic Normal Obese (MHO) is a type of obesity subpopulation that has received much attention in recent years. It is characterized by obesity but with high insulin sensitivity, accounting for 20% -30% of the obese population. Due to the existence of some protective mechanisms, the MHO population is different from the previously mentioned “high-risk and obesity” population in terms of clinical manifestations, inflammation, metabolic profile, treatment and prognosis, etc., and in-depth exploration of its metabolic protection mechanisms and clinical parameters Longitudinal changes are significant for obesity research and health care. This article summarizes the research progress of MHO from epidemiology, defining standards, protection mechanisms, research prospects and so on, and aims to promote the understanding of this important obesity subtype by researchers and clinicians.