高脂膳食对小鼠T细胞的影响

• 出 处: 世界科学
• 发表日期: 2016年07期
• 关键词: 高脂膳食 自身免疫性疾病 细胞分化 生物合成基因 细胞因子 转录因子 脂质代谢 脂肪酸 编码 脂肪酸合成

高脂膳食可通过提高脂质代谢激酶ACC1的表达量,驱动CD4T细胞分化为Th17细胞,从而有可能引发自身免疫性疾病。高脂膳食小鼠进食高脂膳食后,其CD4T细胞即高表达脂肪酸生物合成基因Acaca,该基因可编码ACC1酶(1)。ACC1脂肪酸合成途径的产物促使转录因子RORγt结合在编码细胞因子IL-17A(2)的基因附近。

High-fat diet can promote the differentiation of CD4 T cells into Th17 cells by increasing the expression level of the lipid metabolism kinase ACC1, which may lead to autoimmune diseases. High-fat diet mice fed high-fat diet, the CD4 T cells that high expression of fatty acid biosynthesis gene Acaca, the gene can encode ACC1 enzyme (1). The product of the ACC1 fatty acid synthesis pathway causes the transcription factor RORγt to bind near the gene encoding the cytokine IL-17A (2).