论文部分内容阅读
目的观察吉西他滨(GEM)联合奥沙利铂(OXA)组成的GEMOX方案治疗国人晚期胰腺癌的有效性和安全性。方法晚期胰腺癌22例,应用GEM 1000mg/m2静滴3mim,d1,d8;OXA 100mg/㎡静滴2h,d1,d8,21d重复。至少接受两个周期的化疗,按照WHO标准进行评价。结果22例均可评价疗效,客观有效率18.18%,临床受益疗效分别为疼痛缓解率54.55%,行为状态改善率45.45%,体重状态改善率36.33%。主要不良反应为骨髓抑制、外周神经毒性及胃肠道反应,无治疗相关性死亡。结论吉西他滨联合奥沙利铂组成的GEMOX方案治疗国人晚期胰腺癌近期有效率较高,毒性较低,值得临床推广应用。
Objective To investigate the efficacy and safety of gemcitabine (GEM) combined with Oxaliplatin (GEMX) in the treatment of advanced pancreatic cancer in Chinese. Methods Twenty-two patients with advanced pancreatic cancer were treated with GEM 1000mg / m2 for 3mim, d1 and d8, OXA 100mg / m2 for 2h, d1, d8 and 21d. At least two cycles of chemotherapy are performed and evaluated according to WHO criteria. Results All the 22 cases could evaluate the curative effect. The objective effective rate was 18.18%. The clinical benefit was 54.55%, 45.45% and 36.33% respectively. The main adverse reactions were myelosuppression, peripheral neurotoxicity and gastrointestinal reactions, with no treatment-related deaths. Conclusion GEMOX regimen consisting of gemcitabine combined with oxaliplatin is effective and has low toxicity in the treatment of advanced pancreatic cancer in Chinese people. It is worthy of clinical application.