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目的对比γ干扰素(IFN-γ)释放试验与PPD诊断肺外结核病的效果。方法以2014年1月至2015年10月于我院进行诊断的147例疑似肺外结核病患者为研究对象,分别行IFN-γ释放试验及PPD进行诊断,对比两种方法诊断肺外结核病的灵敏度、特异性、准确度及假阳性率。结果 IFN-γ释放试验诊断灵敏度(79.71%)、特异性(73.07%)和准确度(76.19%)均高于PPD诊断的灵敏度(62.32%)、特异性(37.17%)及准确度(48.98%)(P<0.05);IFN-γ释放试验诊断假阳性率(26.92%)低于PPD诊断假阳性率(62.82%)(P<0.05)。结论 IFN-γ释放试验诊断肺外结核病的灵敏度、特异性、准确度均较高,其假阳性率较低,是诊断肺外结核病的有效辅助方法。
Objective To compare the efficacy of interferon gamma (IFN-γ) release test and PPD in diagnosis of extrapulmonary tuberculosis. Methods A total of 147 patients suspected of extrapulmonary tuberculosis who were diagnosed in our hospital from January 2014 to October 2015 were enrolled in the study. IFN-γ release test and PPD were performed respectively. The sensitivity of the two methods in diagnosing extra-pulmonary tuberculosis , Specificity, accuracy and false positive rate. Results The diagnostic sensitivity (79.71%), specificity (73.07%) and accuracy (76.19%) of IFN-γ release test were all higher than those of PPD diagnosis (62.32%), specificity (37.17%) and accuracy ) (P <0.05). The false positive rate of IFN-γ release test (26.92%) was lower than that of PPD (62.82%) (P <0.05). Conclusions The sensitivity, specificity and accuracy of IFN-γ release test in the diagnosis of extra-pulmonary tuberculosis are high, and its false-positive rate is low. It is an effective adjunct to diagnosing extra-pulmonary tuberculosis.