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自60年代末以来,庆大霉素(以下简称庆大)已广用于临床,因其疗效确实,价格便宜,故深为临床医生乐用,但也有滥用倾向,以致使其主要副作用——肾毒性反应屡有报道,其发生率达2—10％,甚至引起急性肾功能衰竭(ARF)而死亡。本文就近年有关庆大肾毒性作用的文献作一综述,以提醒临床医生加以重视。庆大进入人体后几乎不被代谢,绝大部分自由地经肾小球滤过,其中一部分被近端肾小管曲部及直部重吸收,另外,血液中小部分庆大可经肾小管
Since the late 1960s, gentamicin (hereinafter referred to as Qingda) has been widely used clinically. Because of its curative effect and cheap price, gentamicin is very much used by clinicians, but it also has the tendency of abuse so that its main side effect - Renal toxicity has been reported frequently, its incidence rate of 2-10%, and even cause acute renal failure (ARF) and death. In this paper, the recent literature on the role of Qing-nephritis to make a review to remind clinicians to pay attention. Qing large into the human body after almost no metabolism, the vast majority of free glomerular filtration, part of the proximal renal tubular song and straight part reabsorption, in addition, a small part of the blood can celebrate the tubular