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由于合成有机化学是立足于实践基础之上,加之物理有机化学的发展,对一般典型有机结构的性质及典型反应机制的深入研究,使有机合成化学工作者有可能运用这些理性认识推测未知有机物及其在反应中的内在联系,为设计新化合物和合成方法提供理论指导,从而促进了合成有机化学的发展。可以设想,如果没有已知的研究较清楚的三千多个有机反应作后盾,特别是如果没有那么二百多个在有机合成中有普遍应用价值的有机反应的发展和推广使用,合成有机化学要发展到目前这样的水平是完全不可能的。目前已报导的有机化合物已超过500万个,而且正以每年约15万个的速度迅速增加。与此同时,许多新的反应和新试剂(国外已商品化的有机试剂约五万余种)的开发和使用,如有机锂、有机铜、有机硼、有机铝、有机磷、有机硒、有机硅等新试剂的使用,以及大
Because synthetic organic chemistry is based on practical basis and coupled with the development of physical and organic chemistry, the in-depth study on the properties and typical reaction mechanisms of typical typical organic structures makes it possible for organic synthetic chemists to use these rational understandings to infer the unknown organic compounds and Its internal relations in the reaction provide theoretical guidance for the design of new compounds and synthesis methods, thus promoting the development of synthetic organic chemistry. It is conceivable that if there are no more than 3,000 known organic reactions to organic reactions, and especially if there are not more than 200 organic reactions that have universal application value in organic synthesis, the synthetic organic chemistry To develop to the current level is completely impossible. So far, more than 5 million organic compounds have been reported and are rapidly increasing at about 150,000 annually. In the meantime, many new reactions and new reagents have been developed and used such as organic lithium, organic copper, organic boron, organic aluminum, organic phosphorus, organic selenium, organic The use of new reagents such as silicon, and large