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目的探讨分析黏质沙雷菌败血症伴严重全血细胞减少的临床治疗。方法选取2010年1月~2014年1月经我院诊断并治疗的23例黏质沙雷菌败血症伴严重全血细胞减少患者作为研究对象,对这些患者进行药敏情况及抗生素使用时间分析。结果果绝大多数黏质沙雷菌败血症患者对头孢三代、氨基糖苷类药物与西司他丁及喹诺酮类抗生素敏感,而对青霉素类抗生素不敏感且提前使用抗生素患者出院时间明显短于后使用抗生素患者,P均<0.05,均具有统计学意义。结论早期进行药敏试验培养,并选用高效抗生素进行治疗,可促进黏质沙雷菌败血症的治疗效果,降低死亡率。
Objective To investigate the clinical treatment of Serratia marcescens sepsis with severe pancytopenia. Methods Twenty-three patients with Serratia marcescens sepsis and severe pancytopenia diagnosed and treated in our hospital from January 2010 to January 2014 were enrolled in this study. Drug susceptibility and antibiotic use time were analyzed in these patients. The results of decisive majority of Serratia marcescens sepsis in patients with cephalosporins, aminoglycosides and cilastatin and quinolone antibiotics sensitive to penicillin antibiotics and antibiotics in patients with preemptive discharge was significantly shorter than after the use of Antibiotics patients, P <0.05, were statistically significant. Conclusion Early susceptibility testing culture, and the selection of highly effective antibiotics for treatment, can promote the therapeutic effect of Serratia marcescens sepsis and reduce mortality.