论文部分内容阅读
Objective: To investigate whether or not peri/intraventricularhemorrhages (PIVHs) occurring in the first 12 hours of life (early PIVHs) are related to respiratory distress syndrome(RDS)-associated inflammatory factors in contrast to PIVHs developing after 12 hours of life (late PIVHs). Study design:Blood samples obtained at 0 to 12 hours, 48 to 72 hours, and 168 hours of life were evaluated for determination of the proinflammatory cytokines interleukin (IL)-8 and IL-6, tumor necrosis factor (TNF)-α, and malondialdehyde (MDA) as measures of lipid peroxidation. Simultaneously, cranial ultrasonography was performed in 114 neonates under 32 weeks gestational age. Results: Out of the total study group of 114 neonates, 67(59%) had RDS. Early PIVHs occurred in 16 neonates, 14 ofwhom (88%) had RDS. Late PIVHs occurred in 12 neonates.Neonates with RDS had higher IL-8 and IL-6 levels at 0 to 12 hours (P < 0.0001; < 0.0001) and at 48 to 72 hours (P < 0.001;P< 0.01) than those without RDS. Neonates with early PIVH had higher IL-8 (P< 0.02), IL-6 (P< 0.02), and MDA(P<0.01) levels at 0 to 12 hours than those with late PIVH or no PIVHs. Those with early PIVHs had higher IL-8 levels at 48 to 72 hours than those without PIVHs (P < 0.02). Multiple linear regression revealed an association between RDS/early PIVHs and IL-8, IL-6,and MDA levels. Conclusions: An RDS-associated increase inproinflammatory cytokine and MDA levels was associated with early PIVHs, but not with late PIVHs, suggesting a different etiopathogenesis in early versus late PIVHs.
Objective: To investigate whether or not peri / intraventricular hemorrhages (PIVHs) occurring in the first 12 hours of life (early PIVHs) are related to respiratory distress syndrome (RDS) -associated inflammatory factors in contrast to PIVHs developing after 12 hours of life PIVHs). Study design: Blood samples obtained at 0 to 12 hours, 48 to 72 hours, and 168 hours of life were evaluated for determination of the proinflammatory cytokines interleukin (IL) -8 and IL-6, tumor necrosis factor (TNF) Simultaneously, cranial ultrasonography was performed in 114 neonates under 32 weeks gestational age. Results: Out of the total study group of 114 neonates, 67 (59%) had RDS. Early PIVHs occurred in 16 neonates, 14 ofwh (88%) had RDS. Late PIVHs occurred in 12 neonates. Neonates with RDS had higher IL-8 and IL-6 levels at 0 to 12 hours (P <0.0001; 48 to 72 hours (P <0.001; P <0.01) than those without RDS. Neonat es with early PIVH had higher IL-8 (P <0.02), IL-6 (P <0.02), and MDA (P <0.01) levels at 0 to 12 hours than those with PIVH or no PIVHs. Those with early PIVHs Multiple linear regression revealed an association between RDS / early PIVHs and IL-8, IL-6, and MDA levels. Conclusions: An RDS- associated increase in proinflammatory cytokine and MDA levels was associated with early PIVHs, but not with late PIVHs, suggesting a different etiopathogenesis in early versus late PIVHs.